System Innovation: A Holistic Approach to Disrupting with Love and Human Caring inspires healthcare leaders and professionals to innovate healthcare habits, practices, policies, functions, and their own leadership style to achieve desired outcomes. It employs a holistic approach to leadership and management, providing practical actions for health systems to deploy to disrupt the current environment so a more connected culture, grounded in love and caring, can emerge. Frameworks and theories emphasized include cultural transformation theory, caring science, and design thinking. Calling for a brave visionary approach to leadership, System Innovation is an ideal resource for leadership courses at all levels of nursing and healthcare-related education, as well as in professional settings.