Since human civilization, folks depended on the nature for the daily needs, chiefly to plants as medical and healthy sources. This reliance leads to the development of an exclusive system of knowledge know as Ethnobotany, which consists of the relationship between the plants and their use for various disease & disorder by trial and error methods. The current study is an attempt to gather the ethnomedicinal plants used in Maharashtra to treat multiple disease & disorder. From various revealing literature sources, information has been compiled; mentioning the plants, family, parts used, method of preparation, etc. In Maharashtra, around 417 plant species belonging to 101 families have been used for primary health care. Plants from families like Acanthaceae, Asteraceae, Caesalpiniaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Lamiaceae, Liliaceae, Malvaceae and Poaceae were most frequently utilized in Maharashtra. The folk of Maharashtra used these medicinal plant as a single dose or in combination with others.