Hopeful Monster is the colloquial term used in evolutionary biology to describe an event of instantaneous-speciation, saltation, or systemic mutation, which contributes positively to the production of new major evolutionary groups. The memorable phrase was coined by the geneticist Richard Goldschmidt, who believed that small gradual changes could not bridge the hypothetical divide between microevolution and macroevolution. In Goldschmidt's seminal work The Material Basis of Evolution, he wrote "the change from species to species is not a change involving more and more additional atomistic changes, but a complete change of the primary pattern or reaction system into a new one, which afterwards may again produce intraspecific variation by micromutation." Goldschmidt's thesis however was universally rejected and widely ridiculed within the biological community, which favored the neo-Darwinian explanations of R.A. Fisher, J. B. S. Haldane and Sewall Wright.