High Quality Content by WIKIPEDIA articles! U.S. Route 42 is an east?west United States highway that runs northeast-southwest for 355 miles (571 km) from Cleveland, Ohio to Louisville, Kentucky. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, the Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville, Kentucky. The highway's eastern terminus is in Downtown Cleveland, Ohio. Its western terminus is in Louisville, Kentucky. This road was largely replaced by I-71 in the early 1960s. U.S. 42 crosses into Covington, Kentucky on the Clay Wade Bailey Bridge, joined with U.S. 127 and U.S. 25. Once in Covington, U.S. 42 crosses KY 8 and heads south as Main Street.